Drug Discovery

Cognitive Enhancement

Cognitive-enhancing effects of angiotensin IV: an investigation of molecular mechanisms

Investigator(s): Paul Gard, Ph.D.

Institution(s): University of Brighton

Duration:

Summary:

Angiotensin IV is a metabolite of the neurotransmitter angiotensin II which also serves other functions in the body. The angiotensins effect behavior and neuronal function in animal models. There evidence in humans that therapies known to alter angiotensin activity are associated with modest improvements in cognitive performance. Evidence from animal studies indicates that angiotensin IV, acting via its specific receptor, improves memory and learning without adverse effect. Importantly, this effect is apparent only in aged animals with impaired learning. This project will expand these preliminary animal studies to understand the mechanism of action of angiotensin IV and to begin the process of development of analogues of angiotensin IV more suitable for use in humans.