Glasses of wine

Alcohol - Low to Moderate

  • Food & Drink
  • Updated June 17, 2016

While heavy drinking may lead to dementia in later life, some studies suggest that low to moderate consumption of alcohol—one drink a day for women, two for men—might be beneficial for brain health. The evidence, however, is inconsistent because it is difficult to know whether the beneficial effects are due to alcohol or other factors, such as lifestyle, education, or diet. If you already drink moderate levels of alcohol, it is most likely safe to continue.


Dozens of observational studies and many meta-analyses and systematic reviews report inconsistent conclusions on whether moderate levels of alcohol consumption prevent cognitive decline. Our search identified:

• Multiple meta-analyses and systematic reviews on observational studies
• 0 randomized controlled trials
• Multiple observational studies

Potential Benefit

Although many observational studies have examined whether drinking moderate amounts of alcohol are associated with a reduced risk of developing Alzheimer’s disease, vascular dementia, or age-related cognitive decline, they reached no consensus [1-4]. Observational studies suffer from a number of confounding factors. It is unclear whether the reported benefit from drinking may instead be due to socioeconomic status, cultural background, lifestyle factors, education, or dietary habits. For example, someone who drinks a glass of wine at dinner may also exercise more or eat healthier, which promote brain health. In the short-term, alcohol is well-known to impair cognitive function.

Although it is unclear whether moderate amounts of alcohol can promote long-term brain health, most studies agree that heavy drinking may be associated with cognitive decline or dementia [3].It is likely safe, and potentially even beneficial, to drink moderate amounts of alcohol, but the benefits to brain health aren’t enough to start drinking for this reason.

APOE4 Carriers:

Those with an APOE4 gene allele who drink high amounts of alcohol might be at greater risk for dementia [5][6][7]. However, the evidence for moderate alcohol consumption in those with APOE4 is inconsistent [8][9]. For more information on what the APOE4 gene allele means for your health, read our APOE4 information page.

For Dementia Patients

People with mild cognitive impairment (MCI)? who drink moderate levels of alcohol might be less likely to develop dementia [10][11]. It is possible that other factors explain this effect. For example, MCI patients with greater health problems might be less likely to use alcohol. There is no evidence that alcohol use can slow the progression of cognitive decline in patients with Alzheimer's disease or dementia. Given that alcohol can acutely impair cognitive function and interacts dangerously with many medications, patients with dementia should probably abstain.


Moderate alcohol intake (one drink per day for women, two for men) is generally safe for healthy people. However, heavy drinking is associated with a number of potential side effects including high blood pressure, obesity, stroke, cardiovascular disease, liver disease, certain forms of cancer, and Alzheimer's disease [4][12][13]. For more information on the effects of alcohol on the body, visit the National Institute on Alcohol Abuse and Alcoholism.

NOTE: This is not a comprehensive safety evaluation or complete list of potentially harmful drug interactions. It is important to discuss safety issues with your physician before taking any new supplement or medication.

How to Use

In the United States, moderate alcohol intake is defined as one drink per day for women and two drinks per day for men. A standard drink in the United states is equivalent to roughly 14 grams of alcohol, which is found in 12 ounces of regular beer (~5% alcohol), 5 ounces of wine (~12% alcohol), and about 1.5 ounces of distilled spirits (~40% alcohol).

Learn More

General information on how to define different types of drinking can be found at the Centers for Disease Control, and the National Institute on Alcohol Abuse and Alcoholism.

Information on alcohol’s effects on the body can be found at the National Institute on Alcohol Abuse and Alcoholism.

Check for drug-alcohol and supplement-alcohol interactions on


  1. Beydoun MA, Beydoun HA, Gamaldo AA et al. (2014) Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis. BMC Public Health 14, 643
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