For Researchers

Cognitive Vitality Reports are reports written by neuroscientists at the Alzheimer's Drug Discovery Foundation (ADDF). These scientific reports include analysis of drugs, drugs-in-development, drug targets, supplements, nutraceuticals, food/drink, non-pharmacologic interventions, and risk factors. Neuroscientists evaluate the potential benefit (or harm) for brain health, as well as for age-related health concerns that can affect brain health (e.g., cardiovascular diseases, cancers, diabetes/metabolic syndrome). In addition, these reports include evaluation of safety data from clinical trials, if available, and from preclinical models.

Each report is available as a PDF to download. To view our official Ratings, click here.


Acarbose  Download
Ambrisentan  Download
Angiotensin II Receptor Blockers  Download
Anti-CD33  Download
Anti-IL6 and IL6R mAbs  Download
Aspirin low-dose NSAID  Download
Cannabidiol  Download
Cilostazol  Download
COMT Inhibitors  Download
Dabigatran  Download
Dexmedetomidine  Download
DFMO  Download
Dimethyl Fumarate  Download
DPP-4 Inhibitors  Download
Duloxetine  Download
Edaravone  Download
Efavirenz  Download
EPA  Download
Etifoxine  Download
Fasudil  Download
GLP-1 Receptor Agonists  Download
GM-CSF  Download
Ibudilast  Download
Igmesine  Download
Iron Chelators  Download
IVIG  Download
Leflunomide & Teriflunomide  Download
Lenalidomide  Download
Levetiracetam  Download
Lithium (Microdoses)  Download
Lithium (Pharmaceutical)  Download
Maraviroc  Download

Metformin  Download
Methotrexate  Download
Methylene Blue  Download
Minocycline  Download
Modafinil  Download
Montelukast  Download
Nabilone  Download
Nicotine  Download
Nilotinib  Download
NSAID (Non-Aspirin)  Download
PDE5 Inhibitors  Download
Pentoxifylline  Download
Piracetam  Download
Rapamycin  Download
Rasagiline  Download
Rhein  Download
Riluzole  Download
Roflumilast  Download
Rolipram  Download
Rotigotine  Download
Selegiline  Download
Semax  Download
Sodium Phenylbutyrate  Download
Sulfonylureas  Download
Sulodexide  Download
Suvorexant  Download
Ticagrelor  Download
Trazodone  Download
Vorinostat  Download
Vortioxetine  Download
Zileuton  Download


17α-Estradiol  Download
2-Hydroxybenzylamine  Download
3K3A-Activated Protein C  Download
AAV-hTERT  Download
Allopregnanolone  Download
ANGPTL3-Targeted Therapies  Download
Anti-C1q  Download
Anti-CD22  Download
Apabetalone  Download
AZ-67  Download
Azeliragon  Download
Bardaloxone Methyl  Download
BMS-984923  Download
BPN14770  Download
Cambinol  Download
CSL112  Download
CP2  Download
CT1812  Download
Dapansutrile  Download
DHED  Download
Exosomes  Download
FGF21  Download
Galectin-3 Inhibitors  Download
Ginsenoside Rg1  Download
Ginsenoside Rg3  Download
Homotaurine  Download
IGF1  Download
Immunoproteasome Inhibitors  Download
Intranasal Glutathione  Download
Intranasal Insulin  Download
Intravenous Mesenchymal Stem Cells  Download
ISRIB  Download
J147  Download
Klotho  Download >KPT-350  Download
Ligustilide  Download
L3MBTL1 Inhibitors  Download

Lonafarnib  Download
MANF  Download
MFGE8  Download
MMF Prodrugs  Download
NLRP3 Inhibitors  Download
Nrf2 Activators  Download
Nrf2 PPI Inhibitors  Download
Olamkicept  Download
Omaveloxolone  Download
ORM-12741  Download
Osteocalcin  Download
P110  Download
P38α MAPK Inhibitors  Download
PAR4 Antagonists  Download
Pexidartinib (PLX3397)  Download
Piromelatine  Download
Pridopidine  Download
PRX-03140  Download
PTI-125  Download
RIPK1 Inhibitors  Download
Roluperidone  Download
RTA-405  Download
Senolytics  Download
S6K1 Inhibitors  Download
SFX01  Download
SKQ1  Download
SPG-302  Download
SS-31  Download
SXC-2023  Download
Tanespimycin  Download
Trichostatin-A  Download
Trodusquemine  Download
URMC-099  Download
Urolithin A  Download
VX-765  Download


Blueberries  Download
Cocoa  Download
Green Tea  Download
Olive Oil  Download


Meditation  Download
Molecular Hydrogen  Download
Oxygen Nanobubbles  Download
Sauna  Download
Transcranial Direct Current Stimulation  Download
Transcranial Magnetic Stimulation  Download


AGE   Download
Air Pollution  Download
Aluminum  Download
Benzodiazepines  Download
Diphenhydramine  Download


7,8 Dihydroxyflavone  Download
Alpha-ketoglutarate  Download
Apigenin  Download
Apoaequorin  Download
Astaxanthin  Download
Astragalus  Download
Bacopa Monnieri  Download
Benfotiamine  Download
Berberine  Download
Centella Asiatica  Download
Centrophenoxine  Download
Citicoline  Download
Coffee Fruit  Download
Dinh Lang  Download
D-serine  Download
EGCG  Download
Epithalamin & Epithalon  Download
Ergothioneine  Download
Fisetin  Download
Fucoidan  Download
Genistein  Download
Ginkgo biloba  Download
Glucosamine  Download
Huperzine-A  Download
Kamikihito  Download
Krill Oil  Download
Lions Mane Mushroom  Download
L-Serine  Download
L-Theanine  Download
Magnesium  Download

Medium Chain Triglycerides  Download
Melatonin  Download
MitoQ  Download
N-Acetylcysteine  Download
NDGA  Download
Nicotinamide Riboside  Download
Omega-3 Fatty Acids  Download
Oxaloacetate  Download
Palmitoylethanolamide  Download
Panax Ginseng  Download
Pantethine  Download
Phosphatidylcholine & Lecithin Download
Phosphatidylserine  Download
Plasmalogen  Download
Polyamine  Download
Protandim  Download
Pterostilbene  Download
PTI-00703  Download
Resveratrol  Download
S-Adenosylmethionine  Download
Sage  Download
Soy Isoflavones  Download
Sulforaphane  Download
Tauroursodeoxycholic Acid  Download
TA-65  Download
Tinospora Cordifolia  Download
Trehalose  Download
Triphala  Download
Vinpocetine  Download
Vitamin B6, B12, and Folate  Download