For Researchers

Cognitive Vitality Reports are reports written by neuroscientists at the Alzheimer's Drug Discovery Foundation (ADDF). These scientific reports include analysis of drugs, drugs-in-development, drug targets, supplements, nutraceuticals, food/drink, non-pharmacologic interventions, and risk factors. Neuroscientists evaluate the potential benefit (or harm) for brain health, as well as for age-related health concerns that can affect brain health (e.g., cardiovascular diseases, cancers, diabetes/metabolic syndrome). In addition, these reports include evaluation of safety data from clinical trials, if available, and from preclinical models.

Each report is available as a PDF to download. To view our official Ratings, click here.

DRUGS
 

Acarbose  Download
Allopregnanolone  Download
Ambrisentan  Download
AMX0035 Download
Angiotensin II Receptor Blockers  Download
Anti-CD33  Download
Anti-IL6 and IL6R mAbs  Download
Artesunate Download
Aspirin low-dose NSAID  Download
Atomoxetine  Download
Bacillius Calmette-Guerin Vaccine Download
Baricitinib  Download
Bisphosphonates Download
Bumetanide  Download
Calcium Channel Blockers Download
Cannabidiol  Download
Cilostazol  Download
COMT Inhibitors  Download
CSF-1R Inhibitors Download
Dabigatran  Download
Dexmedetomidine  Download
DFMO  Download
Dimethyl Fumarate  Download
DPP-4 Inhibitors  Download
Duloxetine  Download
Edaravone  Download
Efavirenz  Download
EPA  Download
Estetrol  Download
Etifoxine  Download
Fasudil  Download
Fenofibrate  Download
GLP-1 Receptor Agonists  Download
GM-CSF  Download
Guanfacine  Download
Hachimijiogan Download
Hydroxychloroquine  Download
Ibrutinib  Download
Ibudilast  Download
Igmesine  Download
Iron Chelators  Download
IVIG  Download
Lamivudine Download
Leflunomide & Teriflunomide  Download
Lenalidomide  Download
Levetiracetam  Download
Lithium (Microdoses)  Download
Lithium (Pharmaceutical)  Download
Maraviroc  Download

Metformin  Download
Methotrexate  Download
Methylene Blue  Download
Minocycline  Download
Mirabegron Download
Modafinil  Download
Montelukast  Download
Nabilone  Download
Naltrexone low-dose  Download
Nicotine  Download
Nilotinib  Download
Nitazoxanide  Download
Nooept  Download
NSAID (Non-Aspirin)  Download
Omaveloxolone  Download
PDE5 Inhibitors  Download
Pemafibrate  Download
Pentoxifylline  Download
Pioglitazone Download
Piracetam  Download
Ramelteon Download
Rapamycin  Download
Rasagiline  Download
Retigabine  Download
Rhein  Download
Riluzole  Download
Roflumilast  Download
Rolipram  Download
Rotigotine  Download
Selegiline  Download
Semax  Download
SGLT2 inhibitors  Download
Shingles vaccine  Download
Sodium Oligomannate (GV-971)  Download
Sodium Phenylbutyrate  Download
Sulfonylureas  Download
Sulodexide  Download
Suvorexant  Download
Tacrolimus Download
Ticagrelor  Download
Trametinib Download
Trazodone  Download
Valacyclovir Download
Vorinostat  Download
Vortioxetine  Download
YangXue QingNao Download
Zileuton  Download

 
 
DRUGS-IN-DEVELOPMENT
 

17α-Estradiol  Download
2-Hydroxybenzylamine  Download
3K3A-Activated Protein C  Download
A3R Agonists  Download
AAV-hTERT  Download
Aha1 Inhibitors Download
ALDH2 activators  Download
ALZ-801 Download
Angiotensin 1-7 Download
ANGPTL3-Targeted Therapies  Download
Anti-Atherosclerotic Nanoparticles  Download
Anti-C1q  Download
Anti-CD22  Download
Apabetalone  Download
Apilimod  Download
AR1001  Download
AZ-67  Download
Azeliragon  Download
Bardaloxone Methyl  Download
BIIB080 Download
BMS-984923  Download
BPN14770  Download
Bryostatin Download
Buntanetap Download
Calmodulin-like skin protein  Download
Cambinol  Download
CaMKK2 Inhibitors Download
Carnosic acid  Download
Caspase 2 Inhibitors  Download
CETP Inhibitors Download
cGAS-STING  Download
CK2 Inhibitors Download
CP2  Download
Crisdesalazine  Download
Cutamesine  Download
CSL112  Download
CT1812 (Elayta)  Download
Dapansutrile  Download
DHED  Download
Dihexa Download
DYRK1A Inhibitors  Download
EC5026 Download
EGX358 Download
Elafibranor  Download
ENT1 inhibitors  Download
EP2 Antagonists  Download
Exosomes  Download
FGF21  Download
Fractalkine Modulators Download
FSH blocking antibody Download
Galectin-3 Inhibitors  Download
GDF-11  Download
Gingipain Inhibitors Download
Ginsenoside Rg1  Download
Ginsenoside Rg3  Download
Gintonin  Download
GPR39 Agonists  Download
HBX  Download
HDAC3 Inhibitors Download
Homotaurine  Download
Hsp90 inhibitors  Download
Humanin and humanin analogs  Download
Hydrogen sulfide  Download
Hydroxypropyl-β-cyclodextrin  Download
IBC-Ab002  Download
IGF1  Download
Immunoproteasome Inhibitors  Download
Intranasal Glutathione  Download
Intranasal Insulin  Download
Intravenous Mesenchymal Stem Cells  Download
Irisin Download
ISRIB  Download
J147  Download
Klotho  Download
KPT-350  Download
L3MBTL1 Inhibitors  Download
Ligustilide  Download
LINE1 Inhibition  Download
LM11A-31 (C-31)  Download
Lp(a)  Download
Lonafarnib  Download
Lrp1 Modulators  Download
LXR Agonists  Download
MANF  Download

 

MARK4 Inhibitors  Download
MFGE8  Download
Mitochondrial Transplantation Download
MMF Prodrugs  Download
MOTS-c  Download
MP101/MP201 Download
MSUT2 Inhibitors Download
NE3107 (HE3286)  Download
Nicotinamide Mononucleotide Download
NLRP3 Inhibitors  Download
NNI-362  Download
Notum Inhibitors  Download
NPTX2 Modulator  Download
Nrf2 Activators  Download
Nrf2 PPI Inhibitors  Download
NX210c Download
O-GlcNAcase Inhibitors Download
OGG1 Agonists Download
Olamkicept  Download
ORM-12741  Download
Osteocalcin  Download
P021  Download
P110  Download
P2X7R Inhibitors  Download
P2Y1R Inhibitors  Download
P2Y6R Agonist  Download
P38α MAPK Inhibitors  Download
PAR4 Antagonists  Download
Pepinemab Download
Piromelatine  Download
Plasma exchange  Download
Pomaglumetad  Download
PPARδ Agonists  Download
Pridopidine  Download
Prosaposin Download
PRX-03140  Download
Psilocybin Download 
Rabeximod Download
REST/NRSF Modulators  Download
RIPK1 Inhibitors  Download
Roluperidone  Download
RT001  Download
RTA-405  Download
S1P4R Antagonists Download
S3QELs Download
S6K1 Inhibitors  Download
SAGE-718 Download
SBT-272  Download
Senolytics  Download
SFX01  Download
Simufilam (PTI-125)  Download
SKQ1  Download
Small humanin-like peptides  Download
SPG-302  Download
SS-31  Download
Sterubin  Download
SXC-2023  Download
Syk Inhibitors  Download
T3D-959  Download
Tanespimycin  Download 
THIK-1 Inhibitors Download
THN391 Download
Thyromimetics  Download
TLR2 Inhibitors  Download
TLR4 Inhibitors Download 
Tramiprosate Download
Traneurocin (NA-831) Download
TRH Download
Trichostatin-A  Download
Trodusquemine  Download
Troriluzole Download
TRPM2 Inhibitors  Download 
TRPML1 Agonists Download
TQS-168 Download
URMC-099  Download
Urolithin A  Download
Vafidemstat (ORY-2001) Download
Verdiperstat  Download
Volanesorsen  Download
VX-765  Download
Xanamem  Download
XPro1595  Download

 
 
FOOD/DRINK
 

Acai Berries  Download
Blueberries  Download
Cocoa  Download
Green Tea  Download
Licorice Root  Download
Olive Oil  Download
Royal Jelly  Download
Stevia Download
Wolffia globosa (Mankai) Download

 
NON-PHARMACOLOGIC INTERVENTIONS
 

Breathing Techniques  Download
CPAP for Obstructive Sleep Apnea  Download
Focused Ultrasound Download
Inspiratory Muscle Strength Training Download
Meditation  Download
Molecular Hydrogen  Download
Oxygen Nanobubbles  Download
Sauna  Download
Time-Restricted Eating Donwload
Transcranial Direct Current Stimulation  Download
Transcranial Magnetic Stimulation  Download
Vagal Nerve Stimulation Download
Whole Body Cryotherapy  Download

 
RISK FACTORS
 

AGE   Download
Air Pollution  Download
Aluminum  Download
Benzodiazepines  Download
Diphenhydramine  Download
Epigenetic Clocks  Download
Mold and Mycotoxin  Download
Oxymetazoline Download
Plastics Download
Polygenic Risk Score  Download
Sleep (deficit/excess)  Download
Textile Toxins Download

 
SUPPLEMENTS
 

7,8 Dihydroxyflavone  Download
Aged Garlic Extract  Download
Agmatine  Download
Alpha-GPC  Download
Alpha-ketoglutarate  Download
Apigenin  Download
Apoaequorin  Download
Astaxanthin  Download
Astragalus  Download
Bacopa Monnieri  Download
Benfotiamine  Download
Berberine  Download
Boswellia  Download
Centella Asiatica  Download
Centrophenoxine  Download
Citicoline  Download
Coffee Fruit  Download
Dihydromyricetin  Download
Dinh Lang  Download
D-serine  Download
EGCG  Download
Epithalamin & Epithalon  Download
Ergothioneine  Download
Fisetin  Download
Fucoidan  Download
Genistein  Download
Ginkgo biloba  Download
Glucosamine  Download
Honokiol  Download
Huperzine-A  Download
Kamikihito  Download
Krill Oil  Download
Licorice Flavonoids  Download
Lion's Mane Mushroom  Download
L-Serine  Download
L-Theanine  Download
Lysophosphatidylcholine-Omega3 Download
Magnesium  Download
Medium Chain Triglycerides  Download

Melatonin  Download
MitoQ  Download
N-Acetylcysteine  Download
NDGA  Download
Nicotinamide Riboside  Download
Omega-3 Fatty Acids  Download
Oxaloacetate  Download
Palmitoylethanolamide  Download
Panax Ginseng  Download
Pantethine  Download
PB125  Download
Phosphatidylcholine & Lecithin Download
Phosphatidylserine  Download
Plasmalogen  Download
Polyamine  Download
Postbiotics Download
Probiotics  Download
Protandim  Download
Pterostilbene  Download
PTI-00703  Download
Resveratrol  Download
S-Adenosylmethionine  Download
S-equol  Download
Sage  Download
Selenium Download
Shankhpushpi  Download
Silymarin  Download
Soy Isoflavones  Download
Sulforaphane  Download
Taurine Download
Tauroursodeoxycholic Acid  Download
TA-65  Download
Tinospora Cordifolia  Download
Trehalose  Download
Triphala  Download
Turkey Tail Mushrooms  Download
Ursolic Acid  Download
Vinpocetine  Download
Vitamin B6, B12, and Folate  Download
Vitamin K2  Download