Momentum in Alzheimer’s Research Guided by the Biology of Aging to be Highlighted in Session Moderated by Alzheimer’s Drug Discovery Foundation at 2023 Clinical Trials on Alzheimer’s Disease Conference

ADDF-funded investigators to present research on wide range of novel approaches that will support a combination therapy and precision medicine approach

NEW YORK – (October 17, 2023) – The Alzheimer’s Drug Discovery Foundation (ADDF) will be moderating a session, “Emerging Solutions: Novel Approaches to Treating Alzheimer’s Disease,” at the 2023 Clinical Trials on Alzheimer’s Disease (CTAD) conference, which will be held October 24^th through 27^th at Boston Park Plaza in Boston, Massachusetts. 

This session will highlight the biology of aging and promising drugs in the pipeline that are targeting the many underlying aging pathologies contributing to the onset of Alzheimer’s. This is timely, as 75% of Alzheimer’s drugs in clinical trials are exploring novel targets beyond amyloid and tau. The session will also feature innovative research on regenerative therapies for Alzheimer’s as well as novel approaches for targeting inflammation. 

Howard Fillit, MD, the ADDF’s Co-Founder and Chief Science Officer, will also participate in a roundtable moderated by Philip Scheltens, MD, PhD, Partner and Head of the Dementia Fund at EQT Life Sciences, featuring leading experts and investors in the Alzheimer’s space, including the Dementia Discovery Fund, Alzheimer’s Research UK, and Denali Therapeutics. The panel will discuss the strategic investments needed to accelerate the recent momentum in the field, which is critical for fast-tracking the next generation of Alzheimer’s therapeutics. 

CTAD will feature sessions and keynotes from several ADDF-funded investigators whose work is centered around the biology of aging, which is based on our understanding that novel treatments, diagnostics, and prevention strategies are needed to conquer this disease.

“We’re at the dawn of a new era in Alzheimer's research where we have the first class of drugs on the market targeting amyloid, but there is a broader consensus on the need to develop multiple new therapies based on the biology of aging that can be used in combination with these anti-amyloid drugs,” says Dr. Howard Fillit. “Like other diseases of aging, such as cancer, the ultimate goal for Alzheimer’s treatments is combination therapy and precision medicine, so we can treat each patient’s Alzheimer’s based on their individual biomarker profile.”

Dr. Fillit will participate in multiple sessions that speak to these emerging approaches:

• Session: “Emerging Solutions: Novel Approaches to Treating Alzheimer’s Disease” on Thursday, October 26^th at 9:00 am ET
  • Chair: Howard Fillit, MD

• Roundtable: “Forging the Path Forward: Capitalizing on Recent Alzheimer’s Momentum through Strategic Investments in Novel Therapeutics” on Thursday, October 26^th at 1:20pm ET
  • Moderator: Philip Scheltens, MD, PhD (EQT Life Sciences)
  • Panelists: Howard Fillit, MD (ADDF), John Behr, PhD (Dementia Discovery Fund), Susan Kohlhaas, PhD (Alzheimer’s Research UK), and Joe Lewcock, PhD (Denali Therapeutics)

Additional sessions from ADDF-funded investigators will include:

• Keynote: “Alzheimer’s Disease: The Drug Development Pipeline and Emerging Therapies” with Dr. Jeffrey Cummings on Wednesday, October 25^th at 4:20pm ET

• Late Breaker: “PrecivityAD2 blood test: An analytically and clinically validated test combining p-tau217/np-tau217 and Aβ42/40 ratios to identify brain amyloid” with C2N on Wednesday, October 25^th at 8:45am ET  

• Late Breaker: “Evidence that Lumipulse G pTau217 Plasma measurements have the ability to quantitatively assess Tau stage and burden” with Fujirebio on Thursday, October 26^th at 8:45am ET

To view the full program for the 2023 CTAD conference, visit the conference webpage.