(300 WORDS MAX)Currently there are no effective drugs that prevent the death of nerve cells associated with age-dependent neurodegenerative diseases such as Alzheimer's. These diseases are very complex, and there are many factors that contribute to the patient's demise, yet most drug discovery projects are using an approach that only addresses one of the many aspects of the disease pathology. In this proposal, we are using a different approach to identify drugs for Alzheimer's, one in which drugs are made that hit multiple targets that have not been explored by the pharmaceutical industry, each one of which contributes to the disease.