Even though 5.8 million Americans are currently living with Alzheimer’s disease (a number that is continuing to grow) there are still no preventive or curative treatments available, and it is critical to find new strategies to help maintain cognitive function with aging. Oxidative stress leads to neuron damage and dysfunction, and we have identified a class of reactive harmful compounds that form protein adducts which may be responsible for the damage observed in Alzheimer’s disease. Fortunately, we have developed a therapeutic option that may be able to protect brain cells from the toxic effects of oxidative stress by scavenging the harmful compounds before they can form adducts and damage neurons. In this project, we will evaluate the use of our new therapeutic in older adults over 12 months. We will demonstrate that our new therapeutic can prevent adduct formation and protect brain proteins from damage. While pre-clinical and short-term human safety have already been shown, we will confirm that it is safe for long term use in older adults. We will also collect explore the potential cognitive performance benefits of the therapeutic.