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Life Biosciences

Sharon Rosenzweig-Lipson, PhD | Massachusetts, United States

Life Biosciences

Sharon Rosenzweig-Lipson, PhD | Massachusetts, United States

Effects of Chaperone-Mediated Autophagy in Alzheimer's Disease

The cells of our bodies are continually identifying, moving and breaking down old and damaged materials. This ongoing "quality control" process is critical to the maintenance of not only normal but also disease and aging health. There is a specific type of recycling called Chaperone-Mediated Autophagy (CMA) that is responsible for targeting proteins. As we age and in certain diseases like Alzheimer's Disease, it is believed that the CMA recycling function decreases causing proteins to clump and accumulate resulting in the death of brain cells. It is hoped that using a new class of drugs that activate this recycling process will increase recycling and help to clear this cellular garbage. The hope is that this will keep neurons healthy and functioning to protect memory.