The NMDA receptor is essential for modulating neuronal cell death and has been shown to be a major contributor to the Alzheimer's (AD) related Abeta peptide induced neuronal death. Indeed, memantine, a compound that binds NMDA, is approved for treatment against AD. The problem is that such ligands block ALL NMDA receptors and show serious side effects. Ideally, the perfect compound would target specifically those NMDA receptors involved in AD related neuronal death. We propose to achieve this by creating multivalent ligands, using a novel chemical scaffold, which will allow targeting only the subset of NMDA receptors involved in AD related neuronal death.