The primary objective of the proposed research is to restore brain connectivity and plasticity using non-invasive brain stimulation in patients with FTD and in presymptomatic subjects at risk of developing FTD. A recent study by our group has shown that presymptomatic and symptomatic patients bearing a pathogenic mutation for FTD have an impairment in specific brain circuits and in neural plasticity, which is at the basis of learning, memory and recovery from brain damage, nearly eighteen years before the expected onset of symptoms (Benussi et al., Ann Neurol 2016). In this view, non-invasive brain stimulation techniques, as transcranial direct current stimulation (tDCS), has been shown to induce neural plasticity and to modulate intracortical circuits in healthy subjects, and to improve cognitive functions in patient with neurodegenerative disorders.The proposed research will be carried out in the context of a double-blind, randomized, placebo-controlled trial to explore the effects of repeated sessions of tDCS in patients with overt FTD and in presymptomatic carriers with a genetic mutation for FTD, which already show an impairment in neurophysiological parameters. Using these biomarkers, we can assess the response to treatment also in presymptomatic phases of disease, which is a unique possibility in this field.Within this objective the following research questions will be addressed: 1) Can we restore physiological neural plasticity in the affected areas of the brain?2) Can we reduce the impairment in specific intracortical circuits?3) Is the improvement in cortical circuitry associated with an improvement in cognitive functions in symptomatic genetic or sporadic FTD patients?