Request for Proposal: ADDF-Harrington Scholar Program
The ADDF-Harrington Scholar Program was created to accelerate translation of innovative research efforts that could prevent, treat, or cure Alzheimer’s disease.
The ADDF-Harrington Scholar Program is a collaboration between the Alzheimer's Drug Discovery Foundation (ADDF) and Harrington Discovery Institute. The goal of developing new therapies will be achieved by providing award recipients with both research funding and committed project support by a team of pharmaceutical industry experts.
Award Amount: Up to $300,000 per year for 2 years
- Academic investigators at accredited medical centers, research institutions, and universities in the United States only are eligible to apply.
- Lead investigator must have an MD and/or PhD (or equivalent).
- Proposals should show potential to advance discovery into meaningful therapeutics to treat, prevent, or slow Alzheimer's disease, other dementias, and cognitive aging.
- Novel targets are particularly encouraged.
- The ideal project will be at the stage of active hit-to-lead optimization.
- Team should possess intellectual property (IP) or have potential for new IP.
Areas of Interest
Our current target areas of interest include, but are not limited to:
- Neuronal Energy Failure
- Aberrant Signaling
- APOE and Vascular
- Cognitive Enhancers
Areas of limited interest include: anti-amyloid approaches including anti-amyloid aggregation programs, Abeta vaccine development, beta or gamma-secretase inhibition programs, and cholinesterase inhibitor programs.
Submission and Selection Process
Projects will be assessed on:
• Quality of the science and the scientists
• Novelty and innovative quality of the work
• Potential for impact on human health
Members of the ADDF and Harrington Discovery Institute review panels and Scientific Advisory Boards complete mutual Confidentiality & Disclosure Agreements to protect confidential applicant submissions.
Non-public applicant information is always kept confidential (and limited in distribution to the reviewers and Harrington Discovery Institute and ADDF administrative teams). The executive summary, applicant’s name, and institutional affiliation for those selected as ADDF-Harrington Scholars, may be used by ADDF and Harrington Discovery Institute for publicity and marketing purposes (on the ADDF and Harrington Discovery Institute websites, news releases, etc.) at the ADDF’s and Harrington Discovery Institute's sole discretion.
Sponsoring Institution Requirements
Investigators may apply from accredited academic medical centers, research institutions, or universities in the U.S.
Institutions must provide the necessary facilities and infrastructure for the research, and accept the conditions of the Award, including the Budget & Use of Funds. They must assure compliance with the prevailing national guidelines for animal and human studies and provide proper oversight of the Award funds.
Sponsoring institutions must safeguard the rights and welfare of individuals who participate as subjects in research activities by reviewing proposed activities through an Institutional Review Board (IRB) as specified by the U.S. Department of Health and Human Services Office for Human Research Protections (HHS OHRP). Additionally, the Grantee's institution must assure appropriate governance of animal studies. IRB approval and IACUC numbers are not required at the time of application, but must be provided for final signature of the Grant Agreement, which will be sent to Awardees shortly after they have been selected.
Additionally, sponsoring institutions must adhere to current U.S. Department of Health and Human Services guidelines regarding financial conflict of interest, recombinant DNA, research misconduct and vertebrate animals.
Annual Scientific Symposium
Part of Harrington Discovery Institute's mission is to build a broad connected community of scientists and interaction among awardees as well as with other, preeminent scientists is important. Harrington Discovery Institute will hold each spring in Cleveland, OH an annual symposium that all Harrington Scholars, including ADDF-Harrington Scholars, are required to attend during each year of the grant period. They are expected to present their project and/or findings-to-date. Expenses for travel and lodging will be provided by Harrington Discovery Institute subject to the terms of the Harrington Discovery Institute Grant Agreement.
Award announcements are anticipated for October 2017. The next symposium will be held May 23-24, 2018.
Use of Funds
The awards are provided as milestone-driven payments totaling up to $600,000 over a two year timeframe. Progress will be reviewed regularly by an oversight committee.
Applications and award budgets should be built around key milestones. Milestones are key points in a project, which represent reliable, quantifiable indicators/deliverables of the project’s progress and are used to make decisions on further progress. If an award is made, the Harrington Discovery Institute Innovation Support Center will work with recipients to help refine and manage the milestones.
The project must be structured to deliver a lead product with strong potential for clinical and commercial application.
The awards are conditional on:
- Willingness to work collaboratively with the Harrington Discovery Institute Innovation Support Center staff
- Timely submission of financial and progress reports
- Participation in an Annual Scientific Symposium, organized by Harrington Discovery Institute in Cleveland, Ohio in May of each year
Continued support is dependent upon favorable scientific review of progress reports, milestones being met appropriately, and continued relevance of the work to the mission of the ADDF.
Harrington Discovery Institute and ADDF do not claim rights to patents on discoveries, copyrights, or trademarks to other intellectual property created as a result of work sponsored by ADDF-Harrington Scholar Awards ("Intellectual Property").
On all aspects of Intellectual Property, Principal Investigators are encouraged to confer with their technology transfer office and/or office of sponsored programs for guidance. Grantees should take measures to ensure protection of any Intellectual Property, if appropriate, and then are required to make prompt disclosure of discoveries to the public.
Grants are funded by the ADDF, after the recommendations by the ADDF-Harrington Program Joint Steering Committee. The ADDF-Harrington Program and its review panels and Scientific Advisory Board members do not assume responsibility for the conduct of the project or the acts of the Principal Investigator, since both are under the direction and control of the Principal Investigator's institution and are subject to the institution's medical and scientific policies.
The ADDF-Harrington Initiative reserves the right to refine and amend policies as required.
For program-related inquiries, please contact:
Lauren Friedman, PhD, Acting Director, Scientific Affairs
For application submission inquiries, please contact:
Grants and Contracts Team