The ADDF offers funding to researchers in both nonprofit and for-profit organizations for drug discovery, clinical trials, and biomarker development. Visit our Research Priorities for specific information about our interests.



The majority of funding is provided through four Core Requests for Proposals (RFPs). Letters of intent are accepted and reviewed on a rolling basis during four cycles each year, with corresponding deadlines for invited full proposals. Check back throughout the year for additional funding opportunities through our collaborations with non-profit, government, and industry partners.

Read our policies on application submissions and funding for Core RFPs.


Program to Accelerate Clinical Trials (PACT) RFP

This RFP funds early-stage clinical trials through phase 2 for novel drug candidates, proof-of-concept trials in patients for repurposed/repositioned drugs, and regulatory studies for IND/CTA preclinical packages and drug manufacturing for later stage trials.


Neuroimaging and CSF Biomarker Development RFP

This RFP supports the development and validation of neuroimaging and CSF biomarkers to enhance clinical trials for Alzheimer's disease, related dementias, and cognitive aging.


Prevention Beyond the Pipeline RFP

This RFP supports comparative effectiveness research, prevention clinical trials, and epidemiological studies that probe whether the use or choice of drugs alters the risk for dementia or cognitive decline.


Drug Discovery RFP

This RFP supports programs advancing lead molecules to clinical candidate selection or building preclinical evidence in relevant animal models for repurposed/repositioned drugs.




Accelerating Drug Discovery for Frontotemporal Degeneration RFP

This RFP supports programs advancing lead optimization or in vivo testing of lead compounds, biologics, or repurposed drug candidates for the treatment of frontotemporal degeneration.


Letter of Intent: July 12, 2019
Full Proposal: August 9, 2019


Diagnostics Accelerator: Digital Biomarkers RFP

This RFP seeks to support exploratory, proof-of-principle, and validation studies for digital biomarkers and novel diagnostic technologies for Alzheimer's disease and related dementias. Funding and committed project support from industry experts is provided through a collaboration between the ADDF, Bill Gates, and other partners.


Letter of Intent: Passed
Full Proposal: August 16, 2019


ADDF-Harrington Scholar Program RFP

This RFP supports academic investigators advancing drug development programs from lead optimization through IND-enabling studies. It is a collaboration with the Harrington Discovery Institute, providing award recipients with both research funding and project support by a team of pharmaceutical industry experts.


Letter of Intent: April 12, 2019
Full Proposal: July 19, 2019




ADDF/NIH Funding

Supports NIA and NINDS grant proposals in NIH format that were scored but not funded, which fall within our mission and research priorities.


Conference Funding

Supports scientific conferences that are relevant to our mission with grants up to $10,000. For more information, email with a brief summary of your conference


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